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精确禁止α-Synuclein折叠途径的分子子

Madhusmita Devi1, Sandip Paul1

  • 1Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039 Assam, India.

Biochemistry
|December 5, 2025
PubMed
概括

一个含咖啡因的分子笔有效地抑制了α-synuclein (α-Syn) 错误折叠,这是帕金森病的关键因素. 这种干预通过恢复原生蛋白相互作用来破坏病态聚合,为同核蛋白病变提供治疗潜力.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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