血压,蛋白质血管衰老,以及发生的心血管疾病
Minghao Kou1,2, Xuan Wang1,3, Hao Ma1,4
1Department of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA.
European journal of preventive cardiology
|December 5, 2025
概括
高血压加快了血管衰老,通过血液蛋白质基因分析进行测量. 这种加速衰老可能部分解释高血压和心血管事件之间的联系.
科学领域:
- 心血管医学 心血管医学
- 蛋白质组学是指蛋白质组学.
- 生物老龄化 生物老龄化
背景情况:
- 血液蛋白质分析提供了一种精确的方法来评估生物血管衰老.
- 高血压是心血管事件的主要危险因素.
- 了解将高血压与心血管疾病联系在一起的机制至关重要.
研究的目的:
- 为了研究血压水平和蛋白质血管衰老之间的关联.
- 确定蛋白质血管衰老是否调解高血压和发生心血管事件之间的关系.
主要方法:
- 在45,387名英国生物库参与者中使用21种蛋白质开发了一种蛋白质血管衰老特征 (血管年龄差距).
- 分析了血压类别和连续血压与血管年龄差距之间的关联.
- 进行调解分析,以评估蛋白质血管衰老在高血压相关心血管事件中的作用.
主要成果:
- 血压升高,包括高正常和高血压等级,与血管年龄差距的增加显著相关.
- 观察到的非线性关联是心压和心压血压,值接近120/80毫米升.
- 血管年龄差异介于2级高血压和心血管事件之间的关联的3.73%至10.59%,其中TNFRSF11B和CRLF1是关键蛋白质.
结论:
- 高血压与加速的蛋白质体血管衰老有关.
- 蛋白质血管衰老作为从高血压到心血管事件的途径中的调解者.
- 血管年龄差距是血压相关心血管风险的显著,尽管适度,标记.
相关概念视频
Factors affecting Blood pressure
6.3K
Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
Physiological Factors:
6.3K
Hypertension and Regulation of Blood Pressure
3.6K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.6K
Hypertension II: Pathophysiology
708
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
708
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
521
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
521
Hormonal Regulation of Blood Pressure
5.8K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
5.8K
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
763
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
763


