糖尿病患者的COVID-19:机制,风险和治疗考虑
Rania Hamdy1, Amal Z Barakat2, Eman J Abuzaid3
1Research Institute for Science and Engineering (RISE), University of Sharjah, Sharjah, UAE.
Reviews in medical virology
|December 5, 2025
概括
由于COVID-19的流行,糖尿病通过免疫和代谢途径恶化,增加疾病的严重程度. 了解这种双向关系有助于开发针对糖尿病患者的向疗法.
科学领域:
- * 免疫代谢和传染病.
- *内分泌学和病毒学.
- * 公共卫生和慢性疾病.
背景情况:
- *由SARS-CoV-2引起的COVID-19大流行,给全球健康带来了重大挑战.
- * 糖尿病是一种关键的并发症,与COVID-19风险,严重程度和死亡率的增加有关.
- * 病毒感染和代谢障碍之间的相互作用需要彻底调查.
研究的目的:
- * 审查COVID-19和糖尿病之间的双向关系.
- * 探索潜在的免疫代谢机制.
- * 检查COVID后代谢后续和治疗策略.
主要方法:
- * 在PubMed,Scopus和Web of Science进行了全面的文献搜索.
- *包括到2025年5月发表的同行评审研究.
- *专注于以下术语:"COVID-19"",SARS-CoV-2"",糖尿病"和"免疫代谢".
主要成果:
- *SARS-CoV-2感染通过免疫失调,炎症和β细胞损伤加剧了代谢功能障碍.
- *高血糖会促进病毒的复制和炎症,形成一个有害的循环.
- *观察到新发病和COVID后糖尿病的发病率增加.
结论:
- * 糖尿病通过复杂的代谢和免疫相互作用显著放大COVID-19的严重程度.
- * 了解这些联系为疾病管理提供了洞察力.
- * 支持针对性免疫代谢疗法的开发,以改善患者的治疗结果.
相关概念视频
Pathophysiology of Diabetes
3.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.1K
Diabetes: Management and Pharmacotherapy
848
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
848
Diabetes Mellitus: Type 2 and Gestational
4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Diabetes: Symptoms, Diagnosis, and Complications
2.0K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.0K
Diabetes Mellitus: Overview and Type I Subtype
4.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.8K
Overview of Carbohydrate Metabolism
3.2K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
3.2K


