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脑成像在深度脑刺激后发生变化患有帕金森病的患者:一篇文学评论

Suraiya Mangra¹, Stanislaw Szlufik^1,2,3, Chao-Kai Hu^1,3,4,5

¹Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.

Movement disorders clinical practice

|December 5, 2025

概括

对帕金森病 (PD) 的深度大脑刺激 (DBS) 显示出可测量的大脑变化,包括改变的新陈代谢和连接. 然而,它对大脑结构和功能的确切影响需要进一步研究.

科学领域:

神经成像是一种神经成像.
神经学神经学
神经外科神经外科

背景情况:

帕金森病 (PD) 涉及运动症状和大脑结构变化.
深度大脑刺激 (DBS) 治疗PD运动症状,但其对大脑结构/功能的影响尚不清楚.
对DBS潜在的疾病修饰作用的兴趣越来越大.

研究的目的:

审查神经影像研究在PD患者的DBS后的结构和功能性大脑变化.

主要方法:

在文献中搜索关于帕金森病中DBS后大脑变化的神经成像研究.
对有关新陈代谢,血液流动,功能连接和结构缩的报告研究的审查.

主要成果:

DBS与增加的新陈代谢,血液流动和运动区域的连接性有关.
在DBS后报告了海马和中脑缩.
在非机动区域的功能连接变化是不一致的.

结论:

在PD患者中,DBS会诱导可观测的神经成像变化.
关于DBS对大脑结构和功能的影响的最终结论尚未确定.
需要进行更大规模的标准化研究,以澄清除了减轻症状之外的DBS的影响.

关键词:

帕金森病的疾病.深度大脑刺激刺激大脑神经成像是一种神经成像.

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