相关实验视频

Updated: Jan 9, 2026

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

Published on: January 20, 2022

梯度线程离散扭转双极离子导体 (GTDIG) 的应用,用于高效离子推进和在质谱学中扩展m/z带宽

Zhihao He¹, Xingliang He¹, Fulong Deng¹

¹Research Center of Analytical Instrumentation, School of Mechanical Engineering, Sichuan University, Chengdu 610065, People's Republic of China.

Journal of the American Society for Mass Spectrometry

|December 5, 2025

概括

一个新的无直流梯度螺纹离散扭转双极离子导体 (GTDIG) 扩大了质量测谱中的质量到电荷 (m/z) 带宽. 这种新的离子导体设计在中等真空条件下提高了仪器的灵敏度和性能.

科学领域:

分析化学分析化学
质谱仪器仪器仪表仪器仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表
离子光学离子光学

背景情况:

在质谱学 (MS) 中,仅使用射频 (RF) 多极离子导体,由于碰撞阻尼效应,在中等压力 (0.1-10 Pa) 下,其灵敏度降低,质量到电荷 (m/z) 带宽有限.
现有的离子导体在保持高效率和在特定真空范围内的广泛的m/z传输方面面临着挑战.

研究的目的:

提出和评估一种新的直流 (DC) 无梯度线程离散扭转双极离子导体 (GTDIG).
为了证明增强的离子推进效率和在中等真空 (0.1-10Pa) 中扩展的m/z带宽.
优化关键参数并评估GTDIG概念的性能.

主要方法:

系统地优化GTDIG的工作原理和关键参数.
使用带有离散螺旋电极设计的印刷电路板制造GTDIG.
在一个定制的纳米电子喷雾电离 (ESI) -MS平台上进行多物理数值建模和实验验证.
与传统的四极离子导体进行直接性能比较.

主要成果:

只有射频的GTDIG有效地保持了轴向场,同时与传统指南相比,提供了显著更大的m/z窗口.
新的离散螺旋电极设计使得高效的离子传输成为可能.
实验结果证实了扩展的m/z带宽和在中等真空中提高的性能.

结论:

梯度线程离散扭转双极离子导体 (GTDIG) 提供了一个可行的解决方案,用于克服MS的灵敏度和带宽限制.
这项技术有潜力开发下一代质谱仪器,以提高性能.
无直流GTDIG概念适用于高效率的离子推进应用.

更多相关视频

T-wave Ion Mobility-mass Spectrometry: Basic Experimental Procedures for Protein Complex Analysis

T-wave Ion Mobility-mass Spectrometry: Basic Experimental Procedures for Protein Complex Analysis

Published on: July 31, 2010

Preparing an Isotopically Pure 229Th Ion Beam for Studies of 229mTh

Preparing an Isotopically Pure 229Th Ion Beam for Studies of 229mTh

Published on: May 3, 2019

相关概念视频

Mass Analyzers: Common Types

Mass Analyzers: Common Types

The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...

Electrospray Ionization (ESI) Mass Spectrometry

Electrospray Ionization (ESI) Mass Spectrometry

Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...

Mass Spectrum: Interpretation

Mass Spectrum: Interpretation

An unknown compound can be established by identifying the molecular ion peak in the mass spectrum. The molecular ion peak is often weak or absent due to the predominance of fragmentation in high-energy electron beams. In such cases, a soft-energy electron beam can be used to scan the spectrum to enhance the intensity of the molecular ion peak. Additionally, chemical ionization, field ionization, and desorption ionization spectra are used to obtain a relatively intense molecular ion peak.To...

Mass Spectrometers

Mass Spectrometers

This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:

Ion-Exchange Chromatography

Ion-Exchange Chromatography

Ion-exchange chromatography, or IEC, is a technique for separating ions based on their affinity for the stationary phase. The stationary phase is a cross-linked polymer resin with covalently attached ionic functional groups. The functional groups can be either positively charged (cation exchangers) or negatively charged (anion exchangers). A cation exchanger consists of a polymeric anion and active cations, while an anion exchanger is a polymeric cation with active anions. The choice of...