怀孕前和孕期心脏代谢障碍以及早产和婴儿死亡率的风险
Yangyang Cheng1, Mika Kivimäki2, Yue Zhang1
1School of Public Health, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Journal of global health
|December 5, 2025
概括
怀孕期间多重心脏代谢障碍 (CMD) 显著增加了早产和婴儿死亡的风险. 在怀孕前和怀孕期间早期预防和管理CMD对于改善母亲和婴儿的结果至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 新生儿科学 新生儿科学
- 公共卫生 公共卫生
背景情况:
- 心脏代谢障碍 (CMD) 在怀孕期间对后代的健康构成重大风险.
- 以前对怀孕中集群性心血管疾病的研究往往侧重于有限的条件或时间框架.
研究的目的:
- 调查妊娠前和妊娠期CMD的单个,多个和组合模式与早产和婴儿死亡率之间的关联.
主要方法:
- 美国国家生命统计系统数据 (2014-2020) 对母婴对的分析.
- 检查了六种CMD:怀孕前 (BMI,糖尿病,高血压) 和妊娠期 (体重增加,糖尿病,高血压疾病).
- 采用联合点回归用于流行趋势和多变量后勤回归用于风险关联.
主要成果:
- 观察到CMD数量与早产和婴儿死亡率风险增加之间存在剂量反应关系.
- 同时发生的妊娠前糖尿病和高血压与早产 (OR=10.52) 和婴儿死亡率 (OR=3.93) 有着强烈的关联.
- 特定的组合,如妊娠前糖尿病与妊娠高血压疾病,产生了最高的早产风险 (OR=18.80).
结论:
- 多种CMD的患病率上升与早产和婴儿死亡率的风险增加有关.
- 强调急需加强怀孕前和怀孕期间心脏代谢健康的预防和管理.
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