素问题:基因和生物技术创新,以打击蛋白质营养不良
Varinder Singh1, Manjari Mishra2, Sneh Lata Singla-Pareek2
1National Agri-Food and Biomanufacturing Institute, Mohali, Punjab, India.
Plant, cell & environment
|December 5, 2025
概括
像玉米这样的作物中素缺乏会导致营养不良. 本综述探讨了生物强化方法,包括基因组编辑,以提高氨酸含量,以改善营养和可持续农业.
科学领域:
- 农业科学 农业科学
- 生物技术是生物技术.
- 营养科学 营养科学
背景情况:
- 在主食作物 (玉米,大米,小麦) 中的素缺乏是全球蛋白质营养不良的主要驱动因素.
- 有效的生物强化策略对于应对这种广泛的营养挑战至关重要.
研究的目的:
- 批判性地审查最近在提高作物氨酸含量方面的进展.
- 为了比较传统的育种,代谢工程和基因组编辑方法.
主要方法:
- 关于氨酸生物合成和代过程途径的文献综述.
- 传统育种,代谢工程和CRISPR/Cas基因组编辑技术的分析.
- 探索多omics数据集成和人工智能驱动的预测建模.
主要成果:
- 传统的育种提供了改进,但面临着产量/质量权衡.
- 代谢工程实现了氨酸丰富,但遇到了监管障碍.
- 克里斯普尔/卡斯能够实现精确的无转基因编辑,尽管非目标效应令人担忧.
结论:
- 精密基因组编辑与快速育种相结合,为开发高氨酸,高产作物提供了转型性的方法.
- 这些进展对于实现全球可持续的营养安全至关重要.
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