血中扩大的PD-1hi Tfh细胞在血清阳性临床怀疑的关节痛中预测进展为类风湿性关节炎
Laura Nuño1, Beatriz Nieto-Carvalhal1, Mariana Gutiérrez-Riart1
1Department of Rheumatology, Hospital La Paz, Paseo de la Castellana, 261, Madrid, 28046, Spain.
Rheumatology (Oxford, England)
|December 5, 2025
概括
在疑似类风湿性关节炎 (RA) 的血清阳性个体中,循环卵泡辅助 (cTfh) 和外周辅助 (cTph) T 细胞的升高预测了 RA 的进展. 这一发现有助于识别有针对性治疗的风险患者.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 细胞生物学 细胞生物学
背景情况:
- 临床怀疑关节痛 (CSA) 患者患有类风湿性关节炎 (RA) 的风险增加.
- 识别将从CSA发展为RA的个体对于及时干预和防止不必要的治疗至关重要.
- 循环毛囊辅助细胞 (cTfh) 和外周辅助细胞 (cTph) 的T细胞都与RA的发病有关.
研究的目的:
- 在患有CSA的患者中评估循环Tfh (cTfh) 和Tph (cTph) 细胞频率.
- 为了确定cTfh和cTph细胞频率是否可以预测CSA患者的RA进展.
- 了解cTfh和cTph细胞在RA临床前阶段的作用.
主要方法:
- 前性,非干预性研究设计.
- 从CSA患者和年龄/性别匹配的健康对照 (HC) 收集的外周血液.
- 通过流细胞计分析的外周血液单核细胞 (PBMCs);针对RA发病的患者长达48个月进行随访.
主要成果:
- 血清阳性CSA患者,与血清阴性患者不同,与HC患者相比,cTfh和cTph细胞的频率扩大.
- 较高的基线cTfh和cTph频率在血清阳性CSA患者中观察到,这些患者与非进展者相比,进展到RA.
- 一个cTfh频率>0.66%预测了RA进展,具有72%的灵敏度和85%的特异性.
结论:
- 血清阳性CSA患者表现出基线升高的cTfh和cTph细胞频率.
- 增加的cTfh比例与CSA患者的RA进展有关.
- cTfh和cTph细胞分析可以分层划分进展风险,并指导风险人群的早期治疗决策.
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