挑战认知功能中的肥胖悖论:体重调整的腰指数作为老年人肥胖指标
Xian Lu1, Shiwei Guan1, Lijuan Jiang1
1Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Diabetes, obesity & metabolism
|December 5, 2025
概括
中央肥胖指标,体重调整的腰指数 (WWI) 和腰围 (WC),与老年人认知障碍风险增加有关. 体重指数 (BMI) 显示没有显著的关联,这表明第一次世界大战可能是一个更好的肥胖认知指标.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 中年肥胖是已知的认知障碍风险因素,但其在晚年生活中的作用是复杂的,导致"肥胖悖论".
- 体重调整的腰部指数 (WWI) 是一种新的中心肥胖的指标.
- 关于第一次世界大战与中国老年人认知能力下降的关联,研究有限.
研究的目的:
- 调查第一次世界大战与中国老年人发生的认知障碍之间的关联.
- 在预测认知衰退方面,将第一次世界大战与腰围 (WC) 和体重指数 (BMI) 进行比较.
- 解决了解中心肥胖对老年人群神经认知健康的影响的差距.
主要方法:
- 对5001名年龄≥65岁,认知能力正常的中国成年人的纵向分析.
- 使用中国纵向健康长寿调查的中位数随访时间为4年.
- 时间变化的考克斯比例危险回归和受限立方斜线曲线,以评估第一次世界大战,第二次世界大战和BMI与认知障碍的关联.
主要成果:
- 较高的第一次世界大战四分位数显示认知障碍的发病率增加 (第四季度:13.4%).
- 第一次世界大战与较高的认知障碍风险显著相关 (连续HR=1.14;Q4与Q1HR=1.70).
- 腰围 (WC) 显示出类似的趋势,但身体质量指数 (BMI) 没有显著的关联. 在子组和灵敏度分析中发现的结果是稳定的.
结论:
- 增加WWI和WC,这些是中心肥胖的指标,与老年人发生认知障碍的风险增加有显著的关联.
- 对于肥胖和认知衰退之间的关系,WWI可能比BMI更为精确的标志物.
- 这些发现凸显了中央肥胖评估在监测老年人群认知健康方面的重要性.
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