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恒星细胞FABP7调节了小鼠大脑中依赖活动的蛋白质表达.

Adam P Berg1, Shahroz H Tariq1, Carlos C Flores1

  • 1Elson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.

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概括

天体细胞因子大脑类型脂肪酸结合蛋白 (Fabp7) 通过调节蛋白质体通路来影响发作活动. 这项研究揭示了Fabp7.

关键词:
这就是BLBP.格利亚 (Glia) 是一个.脂质信号传递是如何进行的神经刺激能力的神经刺激能力.蛋白质翻译是蛋白质的翻译.蛋白质组学 蛋白质组学

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科学领域:

  • 神经科学和分子生物学.
  • 天星细胞生物学和研究研究.

背景情况:

  • 发作模式往往与睡眠-清醒周期或白天节律相关.
  • 星体细胞,非神经元细胞,可能在这些发作模式的细胞和分子机制中发挥作用.
  • 大脑类型脂肪酸结合蛋白 (Fabp7) 是一个关键的天体细胞因子,调节了的值和基因表达.

研究的目的:

  • 调查Fabp7对差异性发作活动依赖蛋白质表达的影响.
  • 为了比较Fabp7淘汰赛 (KO) 小鼠与野生型 (WT) 小鼠的蛋白质表达.
  • 在控制条件下分析蛋白质变化,并在最大电击发作值 (MEST) 诱导后进行分析.

主要方法:

  • 来自WT和Fabp7KO小鼠的皮质-海马河提取物的蛋白质组学分析.
  • 使用质谱法 (MS) 来识别蛋白质.
  • 在差异表达蛋白 (DEP) 上进行基因本体学 (GO) 和通路分析.

主要成果:

  • 在KO SHAM与WT SHAM中确定了65个DEP,其中33个是上调和32个是下调.
  • 在WT MEST和WT SHAM中观察到线粒体相关蛋白的下调.
  • 在Fabp7缺乏的小鼠中发现蛋白质体活性升高,由与20S蛋白质体子单元相关的上调DEP表明.

结论:

  • 天体细胞Fabp7调节了日间时间介导的神经刺激性.
  • 这种调节涉及多个细胞机制,包括蛋白质体通路.
  • 这些效应独立于Fabp7在活动依赖基因表达中的先前确定的作用.