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通过集成的MRI-扩散光学成像方法的统计标准化光学数字手腕模型的开发

Tong Zhang¹, Lingxiu Xing¹, Wenjing Sun¹

¹Tianjin University, College of Precision Instrument and Optoelectronics Engineering, Tianjin, China.

Journal of biomedical optics

|December 5, 2025

概括

这项研究引入了一个新的数字手腕 (DW) 模型,集成MRI和扩散光学成像 (DOI) 进行精确的光学健康监测. 开发的解剖学知情模型提高了生物传感精度和临床可靠性.

科学领域:

生物医学光学生物医学光学
医疗成像医学成像
可穿戴的健康技术

背景情况:

目前的光学健康传感器使用简化的模型,导致由于解剖学复杂性和光学可变性导致不准确.
这就需要开发特定器官的光学模型,以实现可靠的生理传感和强大的临床应用.

研究的目的:

通过整合磁共振成像 (MRI) 和扩散光学成像 (DOI) 来创建标准的数字手腕 (DW) 光学模型.
为了实现手腕组织的解剖学准确和光学现实的建模,以提高可穿戴光学健康监测的精度.

主要方法:

实现了一种多模式的MRI-DOI框架,将统计MRI整合用于解剖学DW模板.
使用基于区域的时间域扩散光学断层扫描 (TD-DOT) 与MRI衍生先验用于深度解析的光学特性.
使用空间频域成像 (SFDI) 来获得皮肤表面层的高分辨率光学特性.

主要成果:

基于区域的TD-DOT重建显示了高准确度,光学属性的平均误差低于9.63%.
幻影实验验证了TD-DOT和SFDI的性能,SFDI对表面层的误差较小.
在体内光学属性测量表明与文献值有很强的一致性,证实了方法的可靠性.

结论:

建立了一个标准的DW模板和一个in vivo光学结构采集方法.
生物感知模型从同质的近似转变为解剖学分层模型.
该方法提高了生物传感技术的定制性,动态适应性和临床有效性.

关键词:

数字手腕模板数字手腕模板磁共振成像技术的使用光学数字手腕模型模型空间频域成像空间频域成像时间域扩散光学断层扫描.

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