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功能障碍的默认模式和视觉网络是莱维体痴呆症认知缺陷的基础:休息状态fMRI研究

Zhou Su¹, Mengran Liu², Jun Kuai³

¹Department of Neurology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China.

Frontiers in aging neuroscience

|December 5, 2025

概括

勒维体痴呆症 (DLB) 显示出默认模式和视觉网络中的大脑连接受损,以及局部神经活动受损. 这些静止状态fMRI (rs-fMRI) 发现与认知缺陷相关,这表明DLB的潜在生物标志物.

科学领域:

神经成像是一种神经成像.
认知神经科学认知神经科学
神经学神经学

背景情况:

勒维体痴呆症 (DLB) 是一种神经退行性疾病,其特征是认知能力下降,帕金森症和视觉幻觉.
休息状态网络中的异常功能连接越来越被认为是神经退行性疾病的标志.

研究的目的:

通过静止状态功能磁共振成像 (rs-fMRI) 来调查DLB中的异常功能连接.
探索这些连接异常与DLB患者的认知障碍之间的关联.

主要方法:

68名DLB患者和38名健康对照人接受了全面的神经心理评估 (MoCA,MMSE) 和rs-fMRI.
先进的成像分析包括基于种子的功能连接 (sFC),独立组件分析 (ICA),区域同质性 (ReHo),低频波动的分数振幅 (fALFF) 和图形理论网络指标.

主要成果:

DLB患者在默认模式网络 (DMN) 和视觉网络中显著减少功能连接 (FC),特别是涉及PCC-AG和PCC-mPFC区域.
地方神经同步和低频活动的降低在后叶,角,左极,左部区域和后脑小叶 (ReHo,fALFF) 观察到.
图形理论分析揭示了DLB的全球网络拓结构受损,其特点是减少了小世界性和全球效率. PCC-AG连接和特定区域活动 (fALFF,ReHo) 与各种认知领域有很强的相关性,包括注意力,执行功能,语言,视觉空间能力和记忆.

结论:

DLB的特点是大脑功能网络的广泛破坏,包括DMN和视觉网络,以及局部神经活动和全球网络集成的损害.
识别的rs-fMRI指标反映了功能连接和神经活动的改变,显示了与DLB认知缺陷的显著关联.
这些rs-fMRI发现有望成为量化DLB认知障碍的潜在成像生物标志物.

关键词:

认知障碍是一种认知障碍.默认模式网络模式默认模式网络模式患有利维体痴呆症的痴呆症功能连接性的功能连接性图形理论中的图形理论.静止状态的fMRI进行.

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