儿科群体中不同区域过敏原敏感化模式:对日本和台湾多个抗原同时测试衍生的敏感化概况进行比较性潜阶级分析
Ching-Wei Lin1, Su-Boon Yong2, Rei Kanai3
1Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Asia Pacific allergy
|December 5, 2025
概括
儿童过敏原敏感性在日本和台湾之间有所不同. 家庭灰尘虫敏感性在台湾更为普遍,而吸入剂和多敏感性在日本更为普遍,影响过敏疾病模式.
科学领域:
- 儿科过敏和免疫学
- 环境和职业健康问题
背景情况:
- 过敏原敏感性的区域差异很大,但在儿科患者群体中没有得到充分的研究.
- 很少有研究直接比较日本和台湾之间的儿科敏感性概况.
研究的目的:
- 为了比较来自日本和台湾的儿童的过敏原敏感化模式.
- 使用多个抗原同时测试 (MAST) 和隐性类分析 (LCA) 进行详细的分析.
主要方法:
- 招收了217名日本和166名台湾儿童 (年龄在2-12岁).
- 将参与者分为健康,过敏性鼻炎 (AR),支气管喘 (BA) 或亚托邦性皮肤炎的组.
- 使用MAST分析血清样本,专注于20种共享的过敏原,并应用LCA来识别敏感化模式.
主要成果:
- 确定了四个潜在类别:低敏感性 (LS),家庭灰尘主导 (HDM-D),吸入剂敏感性 (IH-S) 和多敏感性 (PS).
- 在台湾 (50%) 的HDM-D比在日本 (6.9%) 的HDM-D更为普遍.
- 与台湾相比,IH-S和PS类在日本 (分别为36.4%和8.8%) 更常见 (3%和2.4%).
- AR和BA与台湾的HDM-D和日本的IH-S (包括HDM和日本香柏花粉) 有关.
- 在台湾观察到HDM和敏感性之间存在强烈的相关性.
结论:
- 多重抗原同时测试 (MAST) 与潜伏类分析 (LCA) 结合,有效地揭示了儿童不同的区域敏感性概况.
- 这些发现表明,过敏性疾病的发展途径因地理位置的影响而有所不同.
- 了解这些区域差异对于有针对性的过敏预防和治疗策略至关重要.
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