细胞因子在癌症中的"双刃剑"效应:共存的机会和挑战
Xuan Yin1,2, Wangzheqi Zhang2, Guanhua Wang3
1Department of Nursing, Institute of International Medical Science and Technology, Shanghai Sanda University, Shanghai, China.
Frontiers in immunology
|December 5, 2025
概括
细胞因子在癌症中起着双重作用,促进或抑制瘤. 了解它们复杂的网络是开发新的癌症免疫疗法和改善患者治疗结果的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 细胞因子是瘤免疫微环境中的关键信号分子,调解细胞间通信.
- 它们对瘤开始和进展产生"双刃剑"效应,受度,微环境变化和瘤阶段的影响.
- 瘤内的细胞因子网络显著影响癌症的促进,强调需要破坏这种平衡以抑制瘤.
研究的目的:
- 探索细胞因子在癌症进展和免疫反应中的复杂双重作用.
- 研究针对细胞因子网络的新型治疗策略,以改善癌症免疫治疗.
- 阐明细胞因子功能背后的分子机制,以改善临床转化.
主要方法:
- 对瘤免疫微环境中细胞因子网络的现有文献进行审查和分析.
- 检查临床翻译策略,包括细胞因子治疗,免疫检查点阻塞,单克隆抗体和双特异分子.
- 专注于网络视角和协同干预治疗开发.
主要成果:
- 结合的细胞因子治疗和免疫检查点阻塞增强免疫激活和缓解抑制,提高治疗效率.
- 用单克隆抗体等药物向前瘤细胞因子,为克服治疗耐药性提供了新的方法.
- 了解细胞因子的动态调节和双重作用对于推进癌症免疫治疗至关重要.
结论:
- 澄清细胞因子双重效应的分子机制和采用网络视角对于癌症免疫疗法的新范式至关重要.
- 转向"动态调节和协同干预"的策略将改善治疗结果.
- 向细胞因子网络为改善癌症患者的预后提供了有希望的途径.
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