在后COVID状态下结构性大脑异常和神经精神症状
Meghann Ryan1,2, Jared Thomas1,3, Jeremy Wang1
1Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
概括
冠状病毒后疾病 (PCC) 患者表现出更大的大脑结构和相关的神经精神症状,这些症状可能会随着时间的推移而改善. 在PCC中的结构性大脑变化可能表明补偿机制而不是神经炎症.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 冠状病毒后疾病状况 (PCC) 可以表现为持续的神经行为症状.
- 大脑形态变化及其与PCC中神经精神病症状的关系需要进一步调查.
研究的目的:
- 为了在PCC和健康对照中比较大脑形态测量和神经精神症状的横截面和纵向.
- 评估PCC中大脑结构变化和神经行为结果之间的关系.
主要方法:
- 截面和纵向研究比较了29名PCC参与者和25名对照在基线 (感染后~8个月) 和11名PCC和7名对照在随访 (感染后~3年).
- 神经行为评估包括NIH工具箱和患者报告结果测量信息系统 (PROMIS).
- 结构性大脑MRI分析了皮质厚度,表面积和皮质下体积.
主要成果:
- 在基线时,PCC表现出明显更大的肌和杏仁体积,海马和肌体积的趋势更大.
- PCC还显示皮层较厚,皮层表面面积和体积较大,与焦虑,抑郁和疼痛增加有关.
- 在随访时,PCC报告了更多的悲伤,恐惧,疼痛和疲劳,但大脑形态学的群体差异减少了,神经行为表现有所改善.
结论:
- 在PCC中的结构性大脑异常可能反映了补偿过程,如增强的髓化或神经发生.
- 这些变化可能会导致持续的神经行为症状,但证据表明感染后三年可能会有改善.
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