新生儿重症监护室新生儿败血症的病原体分布,抗微生物耐药性和可归因成本分析:一种倾向性得分匹配研究
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Bingyan Zhang1, Peiyun Zhou1, Zongke Long1
1School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Frontiers in pediatrics
|December 5, 2025
概括
新生儿败血症 (NS) 显著增加了中国NICU的住院时间和费用. 这项研究强调了抗菌素耐药性的影响,并呼吁采取综合监测和成本控制措施.
科学领域:
- 新生儿重症监护室 (NICU) 的研究.
- 传染病流行病学传染病流行病学
- 抗微生物药物耐药性的监测监测
背景情况:
- 新生儿败血症 (NS) 在新生儿重症监护室 (NICU) 中存在重大治疗挑战,原因是抗菌素耐药性和医疗保健成本的上升.
- 了解中国NICU中NS的特定致病特征和经济影响至关重要.
研究的目的:
- 分析中国新生儿重症监护室新生儿败血症的致病特征.
- 确定NS对住院时间 (LOS) 和住院费用的独立影响.
主要方法:
- 一个回顾性病例控制研究,涉及978名新生儿在两个三级NICU.
- 倾向性得分匹配 (PSM) 以平衡NS和非NS组之间的基线特征.
- 通用线性模型 (GLM) 用于量化NS归因的LOS和成本,以及病原体和耐药性模式分析.
主要成果:
- NS的发病率为8.28%,其中格拉姆阳性细菌 (71.7%) 主导,特别是Staphylococcus epidermidis (50.5%).
- 观察到高比例的多药耐药 (MDR) 菌株 (65.7%) 和对常见抗生素显著的耐药性.
- NS与11天的LOS增加和每名患者6,035.34美元的额外成本有关,GLM分析显示NS患者的LOS长达3.99倍,成本高达1.68倍.
结论:
- 新生儿败血症大大提高了NICU内的资源消耗.
- 研究结果支持优化抗生素策略和推进医疗保健支付改革.
- 将耐药性监测与成本控制措施相结合,对于减轻NS的健康经济负担至关重要.
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