新生儿呼吸衰竭中维生素D水平的预测值:一项回顾性研究
1Department of Pediatircs, Tianjin Medical University Baodi Hospital, Tianjin, China.
Frontiers in pediatrics
|December 5, 2025
概括
新生儿维生素D缺乏可能会增加呼吸衰竭的风险. 将维生素D水平与妊娠年龄和出生体重相结合,提供了比单独维生素D更好的预测.
科学领域:
- 新生儿医学 新生儿医学
- 营养科学 营养科学
- 儿科呼吸系统健康 儿科呼吸系统健康
背景情况:
- 新生儿呼吸衰竭是发病率和死亡率的重要原因之一.
- 维生素D在免疫功能和整体健康中起着至关重要的作用,新生儿缺乏维生素D很常见.
研究的目的:
- 为了研究早期新生儿维生素D (vit D) 水平对新生儿呼吸衰竭的发展的预测价值.
- 评估将维生素D水平与围产期因素结合起来是否能提高预测准确度.
主要方法:
- 220名住院新生儿的回顾性分析 (2021年3月至2023年3月).
- 血清25-基维生素D [25(OH) D]水平通过化学发光免疫试验测量.
- 对有和没有呼吸衰竭的新生儿进行比较,分析25(OH) D和围产期因素的影响.
主要成果:
- 血清25(OH) D和出生体重是独立的保护因素;妊娠年龄<34周是呼吸衰竭的危险因素.
- 单独维生素D的AUC为0.620,用于预测呼吸衰竭.
- 将25(OH) D与妊娠年龄和出生体重相结合,显著提高了预测准确度 (AUC 0.868).
结论:
- 新生儿维生素D缺乏与呼吸衰竭的风险增加有关.
- 结合25(OH) D水平,妊娠年龄和出生体重的模型表明,与单独使用25(OH) D相比,新生儿呼吸衰竭的预测价值更高.
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