转化脂肪酸对ADHD的影响与肠道微生物群的关系
Nianyang He1, Jiayi Zhong2, Songlin Deng3
1Department of Child Health Care, Xindu Maternal and Child Health Care Hospital, Chengdu, China.
Frontiers in nutrition
|December 5, 2025
概括
饮食中的转脂肪酸 (TFAs) 暴露,特别是在围产期发育期间,与注意力缺陷多动性障碍 (ADHD) 有关. 限制TFAs可以通过保护神经发育和肠道健康来预防ADHD.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 营养科学 营养科学
背景情况:
- 注意缺陷多动症 (ADHD) 是一种由遗传和环境因素影响的神经发育障碍.
- 现代饮食中普遍存在的反式脂肪酸 (TFAs) 是ADHD的环境风险因素.
- TFAs可能通过直接的神经发育损伤或通过肠道微生物群变化间接影响ADHD.
研究的目的:
- 审查在关键神经发育时期 (产前期和青少年) 暴露于转脂肪酸 (TFA) 和注意力缺陷多动症 (ADHD) 之间的关系.
- 探索TFAs影响ADHD病变的机制,特别是通过微生物群-肠-大脑轴 (MGBA).
- 评估饮食中TFA限制作为ADHD预防策略的潜力.
主要方法:
- 文献综述侧重于研究TFA暴露和ADHD的研究.
- 分析与TFA暴露相关的神经发育损伤途径.
- 调查TFA诱导的肠道微生物群失调及其对微生物群-肠道-大脑轴 (MGBA) 的影响.
主要成果:
- 周产期的TFA暴露无疑是有害的,并且与ADHD有关.
- 青少年时期的TFA暴露显示出与ADHD有着有争议的关联.
- TFAs破坏肠道微生物群的稳态,影响MGBA,并导致ADHD的发病.
结论:
- 饮食中限制TFA是一种可行的ADHD预防策略.
- 在神经发育关键时期减少TFA摄入量至关重要.
- 微生物群-肠-大脑轴 (MGBA) 是TFAs影响神经发育和ADHD风险的关键途径.
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