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状炎,这是对塞尔珀卡提尼布的罕见不良反应

Adriana Dias¹, Joao O Pereira¹, Daniela Madama¹

¹Pulmonology Department, Unidade Local de Saúde de Coimbra, Coimbra, PRT.

|December 5, 2025

概括

塞尔珀卡提尼布是用于治疗RET融合阳性肺癌的药物,很少会导致状. 本案例研究表明,剂量降低和饮食有效地控制了这种副作用,而不会影响癌症治疗.

科学领域:

在瘤学瘤学.
胃肠病学胃肠病学
药理学药理学是一个学科.

背景情况:

在转移过程中重新排列 (RET) 融合阳性非小细胞肺癌 (NSCLC) 是一个独特的亚型.
塞尔珀卡提尼布是一种有效的氨酸激酶抑制剂 (TKI),用于RET阳性NSCLC.
状炎 (CA) 是一种罕见但严重的TKI相关的不良事件.

研究的目的:

报告一例因RET阳性肺腺癌而接受塞尔珀卡提尼布治疗的患者的状 (CA) 病例.
描述TKI诱导的CA的管理策略.
评估管理对CA和瘤反应的影响.

主要方法:

一名53岁的男性患有复发性RET阳性肺腺癌,在17个月内发生CA selpercatinib治疗.
治疗包括降低塞尔珀卡提尼布剂量,并开始低长链甘油三糖饮食.
监测了临床反应,形状和瘤反应.

主要成果:

患者在干预后经历了症状缓解和稳定的.
瘤对塞尔珀卡提尼布的反应保持不变.
这种方法有效地管理了CA,而不影响瘤学结果.

结论:

状炎是塞尔珀卡提尼布的一种可控的罕见副作用.
减少剂量和改变饮食的结合可能是有效的.
这种策略允许在解决不良事件的同时继续治疗癌症.

关键词:

状骨炎 (Chylous Ascites) 是一种状骨炎.肺癌是一种肺癌.转基因突变转基因突变塞尔珀卡提尼布 (selpercatinib) 是一种可以氨酸激酶抑制剂氨酸激酶抑制剂

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