慢性胰腺炎中化的危险因素:系统性审查和元分析
Orsolya Eperjesi1,2,3, Jázmin Németh1, Anett Rancz1
1Centre for Translational Medicine, Semmelweis University, Budapest, Hungary.
Frontiers in medicine
|December 5, 2025
概括
酒精和吸烟显著增加了慢性胰腺炎 (CP) 中胰腺结的风险. 减少这些可修改的风险因素对于患者护理至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 胰腺学 胰腺学
- 医学研究 医学研究
背景情况:
- 胰腺化是慢性胰腺炎 (CP) 的常见并发症.
- 这些结与患者发病率增加和医疗保健费用增加有关.
- 导致CP化表型的因素尚不完全理解.
研究的目的:
- 在被诊断为慢性胰腺炎的患者中调查与胰腺结相关的危险因素.
- 确定影响CP中化的发展的关键因素.
主要方法:
- 在PubMed,EMBASE和CENTRAL数据库中进行了系统的文献搜索.
- 分析了80项符合条件的研究数据,涉及31,017名参与者.
- 聚合赔率比率 (OR) 和95%置信区间 (CI) 使用随机效应模型进行计算.
主要成果:
- 饮酒 (OR = 2.31) 和吸烟 (OR = 2.22) 与化的几率增加两倍有关.
- 酒精性CP显示,与异常性CP相比,化的几率高出45% (OR = 1.45).
- 囊性纤维化转膜导电调节器 (CFTR) 突变没有显著增加化风险 (OR = 0.43).
结论:
- 可修改的风险因素,特别是酒精消费和吸烟,与化性CP表型有显著联系.
- 建议将戒烟和减少饮酒计划整合到标准CP护理中.
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