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Updated: Jan 9, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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发现Atirmociclib (PF-07220060):一种强效和选择性的CDK4抑制剂

Gary M Gallego1, Cynthia Palmer1, Suvi Orr1

  • 1Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States.

Journal of medicinal chemistry
|December 5, 2025
PubMed
概括

新的选择性循环素依赖性激酶4 (CDK4) 抑制剂为晚期乳腺癌与减少中性质减退提供了有效的治疗. PF-07220060 (atirmociclib) 通过向CDK4而不是CDK6,从而最大限度地减少副作用,显示出有希望的结果.

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Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics06:00

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