在工业生物制造中Aspergillus niger的进步和潜力
Yingyan Xu1, Dongdong Yang1, Zixuan Guo1
1State Key Laboratory of Microbial Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, China.
Journal of agricultural and food chemistry
|December 5, 2025
概括
尼日尔菌是一种多功能真菌,用于工业代谢物生产. 合成生物学的进步提高了其作为细胞工厂的价值化合物的能力.
科学领域:
- 微生物学 微生物学
- 生物技术是生物技术.
- 合成生物学 合成生物学
背景情况:
- 黑色是一种有丝状真菌,具有强大的安全记录,遗传可处理性和代谢灵活性.
- 它是生产有机酸,酶和二次代谢物等高价值代谢物的理想宿主.
- 最近基因编辑,基因组学和合成生物学方面的进展使得A. niger成为一个高效的细胞工厂.
研究的目的:
- 提供最近使用Aspergillus niger.代谢物生产的进展的全面概述.
- 专注于工程策略,以提高碳来源利用率,新陈代谢途径调节,运输系统和产品分泌.
- 突出新兴的方法,如培诱导和静态基因集群激活,以扩大生物合成潜力.
主要方法:
- 关于最近在Aspergillus niger代谢物生产中的突破的回顾.
- 工程策略的分析,包括碳利用,代谢途径调节,运输增强和分泌.
- 探索新的方法,如培养诱导和静音基因集群激活.
主要成果:
- 工程策略显著提高了A.尼日尔作为细胞工厂的效率.
- 提高碳源利用率,调节代谢途径和改进的分泌系统可以提高代谢物产量.
- 新兴的技术,如共同培养和静音基因激活,释放出新的生物合成能力.
结论:
- 尼日尔虫是一种高度适应的工业生物技术平台.
- 合成生物学工具为优化代谢物生产提供了强大的策略.
- 未来的研究应该专注于为各种应用开发更强大的合成生物学平台.
相关概念视频
01:29Overview of Fungi
1.5K
Fungi are a diverse group of eukaryotes more closely related to animals than other eukaryotes. Fungal cell walls comprise chitin, a polysaccharide that provides structural strength, and glucans, which contribute to flexibility and integrity. Other polysaccharides, such as mannans and galactosans, may supplement or replace chitin in some fungi. These adaptations, along with their preference for acidic environments and tolerance for high osmotic pressure, enable fungi to thrive in various...
1.5K
01:28Fungal Phylum Ascomycota
977
Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
977
01:27Microorganisms in Agriculture and Food industry
1.2K
Microorganisms play a crucial role in agriculture and the food industry, contributing to soil fertility, crop protection, and food production. Their functions range from nitrogen fixation and biopesticide production to fermentation and food preservation, making them indispensable to sustainable farming and food safety.Role in AgricultureNitrogen-fixing bacteria, such as Rhizobium (symbiotic) and Azotobacter (free-living), convert atmospheric nitrogen into ammonia through biological nitrogen...
1.2K
01:30Environmental Applications of Microorganisms
911
Microorganisms play a pivotal role in maintaining ecosystem balance by recycling essential elements such as carbon, nitrogen, and phosphorus, as well as supporting processes like bioremediation, wastewater treatment, and biofuel production.Microbes in Elemental CyclesIn the carbon cycle, microorganisms decompose organic matter, releasing carbon dioxide via aerobic respiration. This carbon dioxide is subsequently used by photosynthetic organisms to synthesize organic compounds, closing the...
911
01:23Microbial Fermentation
1.3K
Fermentation is a crucial anaerobic metabolic process that enables microbes to derive energy from sugar without relying on oxygen or an electron transport chain. This process is fundamental to various biological and industrial applications and is classified based on the metabolic products generated.Role of Pyruvate in FermentationPyruvate and its derivatives serve as key electron acceptors in fermentative pathways. The oxidation of NADH to regenerate NAD+ is essential for the continuation of...
1.3K