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针治疗癌症患者的失眠症

Qin Ma¹, Chunyu Liu^2,3, Guozhen Zhao⁴

¹Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.

The Cochrane database of systematic reviews

|December 5, 2025

概括

与假冒治疗相比,针对患有失眠的癌症患者有不确定的好处. 它可能会略有改善睡眠指标与不活跃的对照对比,但效果不如对失眠的认知行为疗法 (CBT-I).

科学领域:

综合性瘤学综合性瘤学
睡眠医学睡眠医学
基于证据的补充疗法

背景情况:

失眠是癌症患者中普遍存在的问题,严重影响了他们的生活质量.
针是一种常被探索的对失眠的补充疗法,需要在瘤学人群中进行严格的评估.

研究的目的:

系统地评估针治疗癌症患者失眠的疗效和安全性.
综合来自随机对照试验 (RCT) 的证据,将针与假针,非活性对照和失眠认知行为疗法 (CBT-I) 进行比较.

主要方法:

在多个数据库 (CENTRAL,MEDLINE,Embase,PsycINFO) 进行了全面的文献搜索,截至2024年1月.
包括至少为期四周的随机试验,评估治疗癌症患者的失眠.
使用随机效应模型进行了元分析,结果包括失眠严重程度 (ISI),睡眠质量 (PSQI),不良事件和睡眠日记指标 (SOL,WASO,TST,SE). 证据的确定性使用GRADE进行评估.

主要成果:

包括5项研究 (402名参与者),主要是女性乳腺癌患者. 证据确定性被评为非常低至中等.
与假相比,针显示出不确定的效果,一些睡眠日记指标可能略有改善,但整体失眠严重程度或睡眠质量没有显著差异.
与不活跃的对照组相比,针可以改善失眠的严重程度和睡眠质量,尽管不良事件的风险增加. 与CBT-I相比,针对失眠严重程度,睡眠质量,SOL和SE可能效果较差,但可能改善了TST.

结论:

针治疗癌症患者失眠的疗效的证据在很大程度上是不确定的,特别是与假治疗相比.
虽然针可能比不活跃的对照提供一些好处,但它的疗效在关键失眠参数方面可能低于CBT-I.
需要进行更大规模,高质量的长期试验才能得出明确的结论,特别是在多样化的癌症患者群体中.

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