预见COVID-19疫苗接种重新编程胎儿新陈代谢以加速子宫内恢复并抑制持久的代谢记忆

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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

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Roujie Huang¹, Jiyu Xu², Zimo Liu¹

¹National Clinical Research Center for Obstetric & Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Journal of medical virology

|December 5, 2025

概括

怀孕前期的母体无活化COVID-19疫苗接种有助于SARS-CoV-2感染后胎儿的代谢恢复. 接种疫苗可以防止有害的代谢记忆,支持健康的早期生长和发育.

科学领域:

周围生理学周围生理学
免疫学免疫学免疫学
代谢学代谢学代谢学

背景情况:

孕妇在怀孕期间感染SARS-CoV-2可能会影响胎儿的发育.
孕前母体接种疫苗对胎儿恢复的影响尚未完全理解.
建议在生育年龄的妇女接种COVID-19疫苗.

研究的目的:

为了研究预孕不活化的COVID-19疫苗接种对母体SARS-CoV-2感染后胎儿代谢恢复的影响.
分析疫苗接种和未接种疫苗的母亲产生的新生儿的代谢特征.
确定母体疫苗接种所赋予的保护机制.

主要方法:

从新生儿收集带血液样本.
根据怀孕前不活化的COVID-19疫苗接种状态,母亲被分组.
使用超高性能液态染色体-并联质谱法 (UPLC-MS/MS) 进行了代谢分析.

主要成果:

接种疫苗的组显示氨基酸/纯素代谢失调和氧化应激减少.
在5-6个月的IRT窗口中,母体疫苗接种抑制了mTOR信号驱动的病理代谢重塑.
未接种疫苗的新生儿在感染后6个月以上表现出持续的代谢障碍.

结论:

孕前孕期母体无活化COVID-19疫苗接种重新编程胎儿新陈代谢以加速子宫内恢复.
接种疫苗可以防止有害的"代谢记忆"效应,可能降低发育风险.
这些发现支持一种新的,非免疫的,代谢介导的孕产妇疫苗接种的保护机制.

关键词:

根据COVID-19的情况,这是带血,带血.母婴疫苗接种方式代谢生物组的代谢生物组疫苗疫苗疫苗疫苗

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