疫苗接种后眼部不良事件的系统审查:对已发表的报告进行全面分析
Yaru Zou1, Koju Kamoi1, Yuan Zong1
1Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Journal of medical virology
|December 5, 2025
概括
在接种非COVID抗病毒疫苗后,诸如脑膜炎之类的眼睛问题可能会发生,最常见的是流感. 一些病例持续超过四周,突出需要临床医生意识和患者咨询.
科学领域:
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 在COVID-19疫苗接种后记录了眼部不良事件,但对非COVID抗病毒疫苗的数据有限.
- 了解这些罕见的并发症对于患者安全和明智的疫苗接种决定至关重要.
研究的目的:
- 系统地审查和分析与非COVID抗病毒免疫接种有关的眼部并发症.
- 评估这些不良事件的发生率,临床表现和结果.
主要方法:
- 对案例报告,案例系列和观察性研究进行系统的文献搜索 (PROSPERO CRD4202450873).
- 包括122名患者 (184只眼睛) 的数据,涉及流感,VZV,HPV和HBV疫苗的研究.
- 对眼部并发症类型,发病时间,治疗反应和长期结果的分析.
主要成果:
- 尿道炎是最常见的并发症 (50.0%),特别是在接种流感疫苗后 (28.7%).
- 大多数患者 (77.9%) 需要全身性皮质类固醇;84.4%的症状在接种疫苗后30天内开始.
- 很大一部分 (20.0%) 经历了持续的眼部症状 (≥4周),称为"长时间的".
结论:
- 非COVID抗病毒疫苗很少会导致持续的眼部并发症,包括脑膜炎.
- 早期识别,及时治疗和持续监测对于管理这些事件至关重要.
- 临床医生的意识和患者咨询是必不可少的,特别是对于那些接受重复或组合疫苗接种计划的人来说.
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