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相关概念视频

Synteny and Evolution02:31

Synteny and Evolution

3.7K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.7K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

6.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.8K
Karyotyping01:17

Karyotyping

68.0K
Overview
68.0K
Genomics02:02

Genomics

39.6K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.6K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

20.5K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
20.5K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

15.0K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
15.0K

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相关实验视频

Updated: Jan 9, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
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Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

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设置JBrowse 2用于可视化基因组合成.

Colin Diesh1, Garrett Stevens1, Scott Cain2

  • 1Department of Bioengineering, University of California, Berkeley, California.

Current protocols
|December 5, 2025
PubMed
概括
此摘要是机器生成的。

本协议详细使用JBrowse 2,一个开源的基因组浏览器,可视化基因组合成. 它引导用户通过数据准备和设置来探索跨多个基因组的保存序列.

关键词:
进行比较的基因组学.数据可视化数据可视化基因组浏览器 基因组浏览器合成合成合成合成合成整个基因组对齐的整体基因组对齐

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Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens
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Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

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Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization
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相关实验视频

Last Updated: Jan 9, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

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Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens
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Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

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Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization
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Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

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科学领域:

  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • 基因组浏览器是可视化基因组数据的重要工具.
  • 了解合成关系有助于比较基因组学和进化研究.
  • JBrowse 2提供了用于多基因组可视化的高级功能.

研究的目的:

  • 为JBrowse 2中设置合成视图提供协议.
  • 为了展示整个基因组对齐的可视化,用于合成分析.
  • 为了促进跨多个基因组的保存序列的探索.

主要方法:

  • 为全基因组对齐 (WGA) 数据准备数据.
  • 将WGA数据格式化为JBrowse 2兼容的格式.
  • 使用JBrowse 2的图形用户界面 (GUI) 进行交互式合成视图设置.

主要成果:

  • 在JBrowse 2中成功生成合成视图.
  • 从合成可视化创建出版物质量的数字.
  • 展示JBrowse 2对比较基因组学的能力.

结论:

  • JBrowse 2为可视化基因组合成提供了一个有效的平台.
  • 描述的协议简化了对比基因组分析的过程.
  • 这种方法增强了跨物种保护的基因组区域的探索.