[撤回] 宫癌中的Cdc42表达及其对宫瘤入侵和迁移的影响
Hongnan Ye1, Youyi Zhang2, Li Geng1
1Department of Gynecology and Obstetrics, Peking University Third Hospital, Peking University Third Hospital, Beijing 100191, P.R. China.
International journal of oncology
|December 5, 2025
概括
这项研究被撤回,原因是数据重复显著,并在转染,西斑和细胞入侵试验中发现了异常. 在进行独立分析后,该期刊对所呈现的科学数据失去了信心.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 科学出版伦理学 出版伦理学
背景情况:
- 一位读者对转染实验中的数据相似性提出了担忧.
- 最初的担忧促使对该研究的数据完整性进行了审查.
研究的目的:
- 为了解决读者对数据重复的担忧.
- 在论文中提出的实验数据中调查潜在的异常.
主要方法:
- 数字的独立分析,包括转变 (图. 3),西部污染 (图. 4),以及细胞入侵试验 (图. 5) 5) 在这里.
- 对数据面板进行相似性和潜在重复性的比较.
- 对图像数据进行异常的评估.
主要成果:
- 在转染实验中的数据面板之间发现了很高的相似性 (图). 3) 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3). 3).
- 在图中确定了重叠的西部斑块数据. 4. 4. 4. 这是一个很大的问题.
- 在细胞入侵试验数据中观察到重复的数据 (图). 5A和B) 的情况.
结论:
- 由于对所提供的数据缺乏信心,该研究被撤回.
- 在多个实验数字中发现了大量的数据重复和潜在的异常.
- 作者没有为发现的数据问题提供令人满意的解释.
相关概念视频
Inhibition of Cdk Activity
5.5K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.5K
Cancer Cell Migration through Invadopodia
3.2K
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.2K
Cadherins in Tissue Organization
3.8K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Sorting During Development
Cell sorting plays an...
3.8K


