实施失败:在有癌症的门诊患者中进行血栓预防
Elena Butera1,2, Tzu-Fei Wang2, Roberto Pola1
1Thrombosis Unit, Department of Aging, Orthopedic, and Rheumatologic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Hematology. American Society of Hematology. Education Program
|December 5, 2025
概括
静脉血栓栓塞 (VTE) 是 ambulatory 癌症患者常见的,可预防的并发症. 实施基于风险的血栓预防策略可以改善指导方针的遵守和患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 临床药理学 临床药理学
背景情况:
- 静脉血栓栓塞 (VTE) 是癌症患者,特别是接受全身治疗的癌症患者的发病率和死亡率的重要原因.
- 虽然可以预防,但在门诊癌症患者中,VTE发病率仍然很高.
- 风险预测模型,如Khorana得分,有助于识别高风险的个人进行血栓预防.
研究的目的:
- 审查癌症患者血栓预防的证据.
- 探索在临床实践中实施VTE预防指南的障碍.
- 突出成功的策略,以改善血栓预防的采用.
主要方法:
- 关于癌症患者VTE目前证据的文献综述.
- 对阻碍采用血栓预防的因素的分析.
- 检查实施策略及其有效性.
主要成果:
- 低分子量肝素和直接口服抗凝剂对高风险的门诊癌症患者是有效和安全的.
- 尽管有建议,但由于复杂的障碍,血栓预防的使用仍然很低.
- 综合风险计算器,教育和以患者为中心的途径在改善遵守方面显示出有希望.
结论:
- 在门诊癌症患者中有效预防VTE需要解决实施挑战.
- 基于证据的血栓预防可以通过有针对性的策略来改善.
- 弥合指导方针和实践之间的差距对于更好的患者结果至关重要.
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