Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

195
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
195
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

829
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
829
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.6K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Pain in SCD-Many mechanisms and mysteries.

Seminars in hematology·2026
Same author

A novel US-based grading system for disease severity in sickle cell disease: the Sickle Cell Outcome Grading System (SCOGS).

The Lancet. Haematology·2026
Same author

Diagnosis and Management of Acute Chest Syndrome in Children With Sickle Cell Disease.

American journal of hematology·2026
Same author

Acute pain in pediatric patients with SCD without chronic pain is associated with elevated VCAM-1 and P-selectin adhesion.

Blood vessels, thrombosis & hemostasis·2026
Same author

Cortical Thickness Associated with the Degree of Anemia in Children with Sickle Cell Disease.

AJNR. American journal of neuroradiology·2025
Same author

National Alliance of Sickle Cell Centers Consensus Recommendations on Sickle Cell Disease Health Maintenance: A Consensus Statement.

JAMA network open·2025

相关实验视频

Updated: Jan 9, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.9K

优化开始状细胞治疗的正确时间.

Olufunke Y Martin1, Seethal A Jacob2,3

  • 1University of Texas Southwestern Medical Center, Division of Pediatric Hematology-Oncology, Children's Medical Center, Center for Cancer and Blood Disorders, Dallas, TX.

Hematology. American Society of Hematology. Education Program
|December 5, 2025
PubMed
概括

优化状细胞疾病 (SCD) 治疗涉及早期,基于遗传和临床因素的个性化干预. 考虑不断发展的治疗方法的积极方法可以改善SCD患者的生活质量和生存率.

更多相关视频

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.2K
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.3K

相关实验视频

Last Updated: Jan 9, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.9K
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.2K
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.3K

科学领域:

  • 血液学 血液学 血液学
  • 遗传学 是一个遗传学.
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 状细胞疾病 (SCD) 是一种复杂的遗传疾病,导致血液溶解和血管封闭,并有多种并发症.
  • 新生儿查允许早期识别SCD,但疾病修饰疗法 (DMT) 的最佳时机仍在争论中.

研究的目的:

  • 审查遗传,临床和表型因素如何影响SCD中DMT启动时间.
  • 强调朝着早期和个性化SCD治疗策略的不断发展的趋势.

主要方法:

  • 对影响SCD治疗时间的遗传和临床风险因素的文献综述.
  • 对当前和新兴的DMT进行分析,包括氧尿素,L-谷氨胺,克里桑利祖马布,voxelotor,干细胞移植和基因疗法.

主要成果:

  • 对于严重的SCD基因型,支持早期基尿素启动,但面临着不足利用.
  • 越来越多的疗法存在,需要个性化治疗决策.
  • 现型变异性和风险分层是优化干预时间的关键.

结论:

  • 对于SCD管理,需要从反应性到主动性护理模式的转变.
  • 多种药剂方法和生物标志物驱动的策略可能会提高结果.
  • 优化DMT时间改善了SCD患者的生活质量和长期存活率.