一个三级中心的经验,患者与同时的甲状腺髓癌和乳头甲状腺癌
Georgios Boutzios1, Zoe Garoufalia2, Myrto D Keramida2
1Endocrine Unit, Department of Pathophysiology, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi-Attica, 11527, Athens, PC, Greece. gboutzios@med.uoa.gr.
Hormones (Athens, Greece)
|December 5, 2025
概括
这项研究发现,状甲状腺癌 (PTC) 和状甲状腺癌 (MTC) 与患者的年龄或性别等因素并无关联. 这些发现表明,MTC患者的PTC可能是一个偶然的二次发现.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 乳头甲状腺癌 (PTC) 和骨髓甲状腺癌 (MTC) 起源于不同的胚胎组织.
- 已经报告了PTC和MTC在同一淋巴结中的共存,称为混合髓/状甲状腺癌 (MMFTC).
- 同时使用MTC和PTC的临床意义和相关性尚不清楚.
研究的目的:
- 调查MTC患者中PTC的患病率.
- 确定患有同时存在MTC和PTC的患者的临床表型.
- 探索MTC/PTC与临床因素 (如年龄,癌胚抗原 (CEA),素水平,性别和手术数量) 之间的潜在关联.
主要方法:
- 一个回顾性观察性研究是在一个单一的高等大学医院进行的.
- 包括30名在2017年11月至2021年3月期间被诊断为MTC/PTC的患者,不包括那些阳性RET.
- 使用SPSS软件进行了统计分析,包括单变量和多变量分析.
主要成果:
- 该研究包括30名MTC/PTC患者,平均年龄为58.43岁;53.3%是男性.
- 单变体和多变体分析显示,MTC/PTC共存与年龄,素水平,CEA,性别,转移数量或手术数量之间没有显著的关联.
- 样本规模有限限制了多变量分析的范围.
结论:
- 在这个队列中,同时使用MTC/PTC与患者人口统计学或临床标志物之间没有发现关联.
- MTC和PTC的共存可能代表第二种恶性瘤的偶然发现,而不是一个不同的临床实体.
- 需要进一步研究更大的样本大小来证实这些发现.
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