风险堆积对COVID-19相关医疗保健利用的影响:现实世界的回顾性队列研究
Frank R Ernst1, Leah McGrath2, Maya Reimbaeva3
1Pfizer Inc, Cincinnati, OH, USA. Frank.Ernst@Pfizer.com.
Infectious diseases and therapy
|December 5, 2025
概括
患有多种高风险 (HR) 并发症的年轻人面临的COVID-19医疗保健风险比老年人或患有免疫损害条件的年轻人更大. 人力资源状况的"风险堆叠"显著增加了严重COVID-19结果的可能性.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 医疗保健服务研究 医疗服务研究
背景情况:
- COVID-19对健康构成重大风险,特别是对于患有潜在健康状况的人来说.
- 了解多种高风险 (HR) 疾病的累积影响,称为"风险堆叠",对于有针对性的公共卫生干预至关重要.
- 之前的研究集中在个人HR条件上,但多种并发症的协同效应需要进一步研究.
研究的目的:
- 评估"风险堆叠"对不同年龄组和风险类别的COVID-19相关医疗保健资源利用 (HCRU) 的影响.
- 为了比较非免疫功能受损的成年人 (18-49岁和50-64岁) 与免疫功能受损的个人以及65岁及以上的人群中的HCRU.
- 评估多病症和特定的人力资源类别对COVID-19 HCRU的影响.
主要方法:
- 利用了Optum Clinformatics®对一大群成年人 (n=10,631,427) 的数据.
- 根据CDC定义的HR条件对成年人进行分类:HR结论性,HR暗示性,混合证据和没有HR条件.
- 分析了多病症量,人力资源类别和COVID-19 HCRU (住院治疗,ED / UC访问,门诊访问) 之间的关联.
主要成果:
- 最常见的疾病包括高血压 (47.4%),肥胖 (31.9%),慢性心脏病 (CHD; 28.1%) 和糖尿病 (DBT; 20.3%).
- COVID-19 HCRU对于诸如心血管疾病与DBT和心血管疾病与肥胖等组合而言升高,超过了免疫功能受损的个体.
- 跨多个人力资源类别的多重病态性显著增加了所有年龄组中COVID-19 HCRU的调整风险.
结论:
- 患有多种非免疫性疾病的年轻人比不患多种疾病或患有免疫性疾病的老年人更高的COVID-19 HCRU风险.
- 人力资源并发症的"风险堆叠"显然放大了严重COVID-19结果和HCRU的风险.
- 广泛接种疫苗和及时获得治疗对于减轻所有人力资源群体的严重COVID-19影响至关重要,不论年龄.
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