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适应mtDNA内容以耐力训练,横截面研究和耐力训练干预

Isabel María Sánchez Lorente¹, Thomas Yvert², Tamara Iturriaga¹

¹ESBIDA Research Group, Department of Sport Sciences, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, Madrid, Spain.

European journal of applied physiology

|December 5, 2025

概括

高度训练有素的跑步者表现出更高的线粒体DNA (mtDNA) 拷贝数,这与最大氧气吸收 (VO2max) 相相关. 一个为期6周的高强度间歇训练 (HIIT) 计划在以前未经训练的个体中显著增加了VO2max和mtDNA复制数.

科学领域:

运动生理学运动生理学
线粒体生物学线粒体生物学
人类表现的人类表现.

背景情况:

最大氧吸收量 (VO2max) 是心肺健康的一个关键指标.
VO2max与线粒体功能,特别是线粒体DNA (mtDNA) 拷贝数之间的关系尚未完全理解,尤其是在训练有素的人群中.
mtDNA拷贝数反映了线粒体生物发生,并提供了一种评估有氧能力的新方法.

研究的目的:

为了比较高训练的跑步者和久坐不动的男性之间的VO2max和白细胞mtDNA拷贝数.
研究6周高强度间歇训练 (HIIT) 计划对未经训练的个体的VO2max和mtDNA拷贝数的影响.

主要方法:

一项涉及20名训练有素的跑步者和20名未经训练的男子的横截面研究.
在未受过训练的组中,实施了为期6周的HIIT计划 (4分钟工作/4分钟休息,3次/周),并对对照组进行了监测.
干预前后测量VO2max和白细胞mtDNA拷贝数.

主要成果:

与未受过训练的人相比,训练有素的跑步者表现出明显更高的mtDNA复制数 (p=0.046).
在两组的mtDNA拷贝数和VO2max之间发现了显著的正相关性 (R2=0.153).
在干预组中,6周的HIIT计划导致VO2max (p<0.001) 和mtDNA拷贝数 (p=0.015) 的显著增加,观察到实质性的个体间变异性.

结论:

白细胞mtDNA拷贝数与VO2max积极相关,并且在耐力训练的个体中升高.
6周的HIIT干预有效地增加了未经训练的个体的VO2max和白细胞mtDNA拷贝数.
这些发现突显了线粒体内容在应对有氧训练时的适应潜力,并表明了个体反应的变化.

关键词:

长时间的HIIT.线粒体生物发生是线粒体生物发生.跑步跑步跑步跑步跑步机训练训练跑步机训练 mtDNA复制号码 mtDNA复制号码

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