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Updated: Jan 9, 2026

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
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使用蛋白质语言模型设计一个不稳定的RNase A

Gabriel Ong1, Kiat Whye Kong2, Si En Poh2

  • 1Institute of Sustainability for Chemicals, Energy and Environment, A*STAR, Singapore, 627833, Singapore.

ACS synthetic biology
|December 5, 2025
PubMed
概括

研究人员设计了一种不太稳定的酶变体TempRNase,它保留了RNA降解活性,但很容易被禁用. 这为分子生物学工作流提供了一个简化的替代方案,通过简化酶去除和减少实验复杂性.

关键词:
蛋白质的设计 蛋白质的设计蛋白质工程工程 蛋白质工程蛋白质语言模型的模型核糖核酸酶是一种核糖核酸酶.

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