对淋巴细胞食道炎的治疗选择进行系统审查
Bachviet Nguyen1, Chun Fang Cheng2, Fahd Jowhari3
1Department of Medicine, University of British Columbia, 13750, 96 Ave. Critical Care Tower, 3rd Floor, Surrey, British Columbia, V3V 1Z2, Canada.
概括
局部类固醇可能为淋巴细胞食道炎 (LyE) 提供比质子抑制剂 (PPI) 更好的症状和组织学改善,但复发更频繁. PPI仍然是LyE治疗的安全初始选择.
科学领域:
- 胃肠病学 胃肠病学
- 食道疾病 食道疾病
- 免疫学 免疫学 免疫学
背景情况:
- 淋巴细胞食道炎 (LyE) 是一种罕见的食道疾病,其特征是内皮细胞淋巴细胞透.
- 目前对LyE的最佳治疗策略尚不确定.
研究的目的:
- 系统地审查和综合目前关于淋巴细胞食道炎治疗的证据.
主要方法:
- 按照PRISMA指南进行了系统审查,搜索了MEDLINE,Embase和谷歌学者.
- 如果这些研究提供了关于LyE治疗结果的初级数据,则将研究纳入.
主要成果:
- 分析了涉及154名患者的39篇文章.
- 局部类固醇对LyE的反应率高于质子抑制剂 (PPI).
- 气球扩张对消化不良是有效的; 其他治疗包括生物药物和内镜注射.
结论:
- 局部类固醇在LyE症状和组织学改善方面似乎比PPI更有效,尽管复发率更高.
- PPI可能是对LyE的合理一线治疗,特别是当安全优先考虑时.
- 需要进一步的研究来比较各种LyE治疗方式的疗效和安全性.
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