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SII-PNI得分:一种新的复合生物标志物,用于个性化预测腹腔透析患者的死亡风险

Min Zhou¹, Guoyi Wang¹, Ping Yue¹

¹Department of Nephropathy, The Affiliated Huai'an NO.1 People's Hospital of Nanjing Medical University, Huai'an, China.

|December 5, 2025

概括

一个新的SII-PNI得分准确地预测了腹膜透析 (PD) 患者的死亡风险. 这种简单的血液检查有助于个性化护理,并识别高风险个体,以便及时介入.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
免疫学免疫学免疫学
生物标志物发现发现

背景情况:

准确的风险分层对于定制腹腔透析 (PD) 管理至关重要.
现有的生物标志物可能无法完全捕捉PD患者的复杂死亡风险.
需要新的方法来准确预测PD的结果.

研究的目的:

开发和验证SII-PNI得分,整合系统性免疫-炎症指数 (SII) 和预后营养指数 (PNI).
评估得分在预测全因,心血管疾病 (CVD) 和PD患者感染相关死亡率方面的有效性.
将SII-PNI得分的预测性能与单个组件和CRP进行比较.

主要方法:

对330名PD患者进行了回顾性队列研究.
在SII和PNI的基础上分为四个风险组的分层.
卡普兰-梅尔生存分析和多变量考克斯比例危险模型来评估死亡风险.
接收器运行特征 (ROC) 曲线用于评估预测性能.
随机生存森林以确定变量重要性.

主要成果:

高SII/低PNI组与低SII/高PNI组相比,对所有原因,心血管疾病和感染相关死亡的风险显著更高.
与单独的SII,PNI或CRP相比,SII-PNI得分显示出更高的预测能力 (AUC范围从0.80到0.81).
关键的血液参数 (血小板,中性粒细胞,淋巴细胞,白蛋白) 被证实是预测结果的关键预测因素.

结论:

SII-PNI评分是一个强大的,方便的生物标志物,用于PD患者个性化风险分层.
通过SII-PNI得分识别的高风险患者需要加强监测和早期干预.
这种复合生物标志物促进了PD护理中的精准医学,并且可以使用标准实验室数据实现.

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