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里斯佩里对健康成年人氨基酸代谢,葡萄糖和功能的影响:试点随机对照试验
Megumi Oshima1, Tadashi Toyama1,2, Yusuke Nakade3
1Department of Nephrology and Rheumatology, Kanazawa University, Kanazawa, Japan.
PloS one
|December 5, 2025
概括
在健康的成年人中,短期使用Risperidone会增加d-氨酸水平,但不会影响功能或葡萄糖平衡. 这项研究探讨了RISPERIDONE.
科学领域:
- 药理学 药理学是指药理学的学科.
- 代谢研究研究 代谢研究
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 在急性损伤模型中,D-氨酸的使用显示出保护作用.
- 里斯佩里顿抑制d-氨基酸氧化酶,影响血d-氨基酸水平.
- 了解RISPERIDONE对氨基酸代谢和功能的影响至关重要.
研究的目的:
- 对健康成年人的葡萄糖和氨基酸代谢对短时间的RISPERIDONE的作用进行研究.
- 评估RISPERIDONE对功能的影响,包括估计的膜过率 (eGFR) 和尿蛋白.
- 为了评估在瑞斯比治疗后对胰岛素耐药性 (HOMA-IR) 稳态模型评估的变化.
主要方法:
- 试点随机对照试验涉及健康成年人的HOMA-IR≥1.6和eGFR≥60mL/min/1.73m2.2.
- 参与者被随机分配,接受0.5毫克/天的Risperidone或安慰剂4天.
- 主要结局:HOMA-IR的变化;次要结局:d-氨基酸水平,eGFR和尿蛋白的变化.
主要成果:
- 在RISPERIDONE和对照组之间没有观察到HOMA-IR,eGFR或尿蛋白变化的显著差异.
- 与对照组相比,Risperidone组中发现了血d-serine水平和尿液d-serine/肌素比率的显著增加.
- 在健康个体中,短期使用瑞斯佩里并没有对功能或葡萄糖平衡产生急性不良影响.
结论:
- 短期使用Risperidone会影响健康成年人的d-serine代谢.
- 在这个人群中,瑞斯比似乎不会对脏或葡萄糖平衡产生急性不良影响.
- 需要进一步的研究来探索这些代谢变化的长期影响.
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