通过生物信息学策略识别和验证动脉样硬化进展的诊断标志物
Yun Mao1,2, Yang Xiao1,2, Xia Hu2,3
1Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
PloS one
|December 5, 2025
概括
这项研究确定了关键基因,这些基因与血管硬化 (AS) 中的细胞内网膜压力和线粒体损伤有关. 这些发现为开发有效的药理治疗心血管疾病提供了新的目标.
科学领域:
- 心血管生物学 心血管生物学
- 分子医学是分子医学.
- 生物信息学是一种生物信息学.
背景情况:
- 动脉样硬化 (AS) 是心血管疾病的主要原因,其潜在机制尚不清楚.
- 了解AS病原体对于减少社会和家庭负担至关重要.
研究的目的:
- 使用生物信息学阐明动脉样硬化 (AS) 的机制.
- 为了确定潜在的药理治疗AS进展.
主要方法:
- 分析了GSE28829数据集,用于AS斑块中的差异性基因表达.
- 专注于与内质网膜 (ER) 压力和线粒体损伤相关的交叉基因.
- 使用了LASSO回归,蛋白质-蛋白质相互作用网络和免疫细胞透分析 (ssGSEA,CIBERSORT).
主要成果:
- 在AS中确定了差异表达基因 (DEG) 和关键枢纽基因 (例如FCGR3A,ITGB2,TYROBP).
- 在枢纽基因,免疫过程,ER压力和线粒体损伤之间发现了强烈的相关性.
- 开发了一种具有显著预测价值的AS诊断模型.
结论:
- 参与ER压力和线粒体损伤的基因在AS病变发生过程中发挥作用.
- 鉴定到的枢纽基因为AS研究和药物开发提供了新的目标.
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