基于石灰的补充剂可以减少氧酸盐石头的复发:一个多中心随机对照试验
Thasinas Dissayabutra1,2, Weerapat Anegkamol1, Supoj Ratchanon3
1Metabolic Disease in Gastrointestinal and Urinary System Research Unit, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
PloS one
|December 5, 2025
概括
一种基于石灰的新型制剂 (LPR) 与安慰剂相比,在两年内显著减少了76%的结石复发. 这种富含植物化学物质的饮食也降低了炎症标志物,为预防石头提供了一个安全的替代方案.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 植物化学 植物化学
背景情况:
- 复发性泌尿质炎是一个重大的临床挑战,高复发率会影响患者的生活质量.
- 酸是有效的,但受到坚持问题 (成本,副作用) 的限制.
- 基于石灰的干预措施有望增加尿中酸盐和性.
研究的目的:
- 评估基于石灰的富含植物化学物质 (LPR) 治疗方案在预防结石复发方面的有效性和安全性.
- 在24个月内评估LPR对尿路炎症标志物的影响.
主要方法:
- 一个多中心,双盲,随机对照试验,涉及173名患有氧化尿病的患者.
- 参与者接受了24个月的LPR或安慰剂.
- 主要结局:通过CT扫描再次出现石头. 二次结果:尿蛋白和IL-8水平.
主要成果:
- LPR显著减少了石头的复发,使得石头的复发率降至14%,而安慰剂的45% (p < 0.001).
- 卡普兰-梅尔分析显示,LPR复发风险降低了76% (HR 0.24).
- 尿路LPR降低了尿路IL-8和蛋白质分泌;粘附率高,没有严重的不良事件.
结论:
- 酸氧化可以有效地减少酸氧化石的复发,可能是通过增加酸盐,化和减少脏炎症.
- 观察到尿路IL-8和蛋白尿的减少支持LPR的抗炎作用.
- 乳腺皮质再生是一种安全,经济高效的二次性石头预防方案,特别是在对传统疗法不耐受的患者中.
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