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相关概念视频

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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相关实验视频

Updated: Jan 9, 2026

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

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T-SCAPE:通过跨域辅助预测引擎进行T细胞免疫性评分.

Jeonghyeon Kim1, Nuri Jung1, Jayyoon Lee2

  • 1Department of Chemistry, Seoul National University, Gwanak-gu, Seoul 08826, Republic of Korea.

Science advances
|December 5, 2025
PubMed
概括

预测T细胞免疫性对于更安全的疫苗和疗法至关重要. 一个新的深度学习框架,T-SCAPE,整合了各种数据,以准确预测T细胞激活和治疗抗体免疫性.

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Last Updated: Jan 9, 2026

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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科学领域:

  • 免疫学 免疫学 免疫学
  • 计算生物学 计算生物学
  • 生物技术是生物技术.

背景情况:

  • 对于疫苗和治疗性蛋白质的开发,T细胞免疫性至关重要.
  • 由于有限的数据和复杂的生物相互作用,预测免疫性是具有挑战性的.
  • 目前的方法难以对T细胞反应进行全面的in silico预测.

研究的目的:

  • 开发一种新的深度学习框架,T-SCAPE,用于预测T细胞免疫性.
  • 整合多种免疫学数据源,以提高预测准确度.
  • 评估T-SCAPE能够预测T细胞激活和治疗抗体免疫性的能力.

主要方法:

  • 通过跨域辅助预测引擎 (T-SCAPE) 开发了T细胞免疫性评分,这是一个多域深度学习框架.
  • 采用对抗性域调整来整合MHC表现,pMHC结合,TCR-pMHC相互作用和T细胞激活的数据.
  • 经过验证的T-SCAPE使用泄漏控制的基准来预测T细胞激活和抗药抗体诱导.

主要成果:

  • T-SCAPE在预测特定-MHC对的T细胞激活方面表现出色.
  • 该框架准确地预测了没有MHC输入的治疗抗体的抗药抗体诱导潜力.
  • 基于生物相关性和数据的多领域预训练对T-SCAPE的成功做出了重大贡献.

结论:

  • T-SCAPE提供了一种强大而准确的方法来预测T细胞免疫性.
  • 该框架集成多样化的数据的能力增强了其预测能力.
  • T-SCAPE有可能大大推动更安全,更有效的疫苗和蛋白质疗法的开发.