在哥伦比亚2023-2024年爆发期间登革热病毒感染的流行病学和严重性风险因素
Daniela Torres-Hernández1, Nathan D Grubaugh2,3, Mónica A Murillo-Ortiz4,5
1Department of Pediatrics, Universidad del Valle, Cali, Colombia.
PLoS neglected tropical diseases
|December 5, 2025
概括
这项研究确定了大流行期间严重登革热表现的风险因素,发现居住在城市以外的地区和高白细胞计数增加了风险. 早期识别严重的登革热至关重要,强调需要对所有血清型进行广泛保护.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 美洲在2023-2024年经历了最大的登革热流行.
- 使用详细的登革热分类来识别严重表现的患者.
研究的目的:
- 描述与严重登革热表现相关的风险因素.
- 为了确定预测严重登革热后果的患者特征.
主要方法:
- 哥伦比亚600名病毒学确诊登革热 (VCD) 患者的前性队列研究 (2023年4月至2024年9月).
- 进行登革热病毒 (DENV) 血型和基因型鉴定.
- 多变量后勤回归用于识别严重登革热表现的风险因素,根据世卫组织标准和特定临床指标定义.
主要成果:
- 严重的登革热表现发生在28%的患者 (n=167),包括严重的登革热和具有警告迹象的登革热 (DwWS) 与更严重的过程.
- 严重表现的独立风险因素包括居住在城市之外,胀和白细胞数量较高.
- 较低的严重表现的几率与较高的血小板和淋巴细胞计数以及非DENV-2感染有关.
结论:
- 疫情涉及多个DENV血清型和基因型,主要影响儿童和青少年.
- 识别风险因素可以提前识别严重的登革热.
- DENV-2与更高的风险有关,但建议使用四价值保护,无论之前的暴露是如何,因为无法预测的严重登革热动态.
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