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在静脉内注射后预防内炎的抗生素预防:更新的系统审查和元分析

Yuri Aleksander-Ivanov¹, Lidia Cheidde², Luiz Alberto Zago Filho^3,4

¹Faculty of Medicine, University of Southern Santa Catarina (UNESC), Criciuma, SC, Brazil.

Retina (Philadelphia, Pa.)

|December 5, 2025

概括

在静脉内注射 (IVI) 后,局部抗生素预防并不能降低内炎风险. 事实上,它可能会增加抗VEGF IVI的风险,这表明例行预防不合理.

科学领域:

眼科医生眼科眼科
传染性疾病传染性疾病
基于证据的医学基于证据的医学.

背景情况:

视内膜炎是静脉内注射 (IVI) 的严重并发症,可能导致视力丧失.
抗生素预防的临床实践在全球范围内有所不同,关于其有效性的争论仍在进行中.
评估预防策略对于患者的治疗结果和资源分配至关重要.

研究的目的:

系统地审查和元分析局部抗生素预防在IVI后预防内炎的疗效.
评估抗生素预防对各种IVI类型内眼炎发病率的影响.
为日常使用抗生素预防提供基于证据的建议.

主要方法:

对PubMed,Embase,Cochrane和Web of Science研究的系统审查和元分析,截至2025年7月.
包括比较IVI内炎发病率与没有抗生素预防的研究.
使用随机效应模型进行数据合成,并使用ROBINS-I工具评估偏差风险.

主要成果:

分析了22项涉及580多万 IVI 的研究.
在抗生素预防时,没有发现内炎发病率的显著整体降低 (p=0.09).
亚组分析显示,在抗VEGF注射中使用抗生素预防时,内炎的风险显著增加 (OR 1.56,95% CI 1.03-2.36).

结论:

局部抗生素预防与IVI后内炎风险的降低无关.
在接受抗VEGF注射的患者中,抗生素预防可能会增加内炎风险.
目前的证据不支持对IVI进行局部抗生素预防的常规使用.

关键词:

抗生素抗生素是一种抗生素.末端的形形形形内注射内注射内注射进行元分析,预防和预防.系统性审查系统性审查

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