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Updated: Jan 9, 2026

Techniques to Induce and Quantify Cellular Senescence
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Published on: May 1, 2017

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诺西丁介导的SIRT6下调驱动细胞衰老在质母细胞瘤

Yankai Xu1, Jiesi Zhou1, Xiaobin Zhou1

  • 1Department of Neurosurgery, The First Affiliated Hospital of Shantou University Medical College, Shantou City, Guangdong Province 515041, China.

Neuropeptides
|December 5, 2025
PubMed
概括

诺西丁 (N/OFQ) 信号通过降低SIRT6的调节促进质母细胞瘤 (GBM) 衰老,从而增加p53乙化和p21表达. 用抗体阻断N/OFQ受体 (NOPr) 抑制这种衰老,这表明一种新的治疗策略.

关键词:
质母细胞瘤 (glioblastoma) 是一个在Nociceptin中使用.在SIRT6上.衰老是一种衰老.在 p53 里,p53 是一个 p53 的类型.

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