关于激光表面微结构系统的研究进展,用于从骨科植入物中储存和释放药物.
Yumei Bao1,2, Zhiwei Chen1, Heng Zhang1
1College of Mechanical Engineering, Zhejiang University of Technology, Hangzhou 310023, People's Republic of China.
Biomedical materials (Bristol, England)
|December 5, 2025
概括
激光技术精确地控制了骨科植入物上的微/纳米结构,以增强药物输送,对抗感染和改善骨质整合,以获得更好的外科结果.
科学领域:
- 生物材料科学 生物材料科学
- 整形外科手术 整形外科手术
- 激光处理技术 激光处理技术
背景情况:
- 手术后感染和骨质整合不良是骨科植入物失败的关键挑战.
- 植入物中集成的药物储存和释放功能提供了一个有希望的解决方案.
- 微/纳米拓结构对于有效的药物加载和受控释放至关重要.
研究的目的:
- 系统地审查激光技术在制造骨科植入物上的药物储存和释放微结构中的应用.
- 突出激光处理在增强植入物功能的作用,以改善患者的治疗结果.
- 分析当前的挑战和未来的方向在这个领域.
主要方法:
- 关于植入物表面微结构设计和制备方法的文献综述.
- 专注于超快激光技术,用于制造微/纳米拓结构.
- 重点是激光增材制造,以创建具有分级孔隙性的复杂支架.
主要成果:
- 激光技术可以精确控制微/纳米结构,从而实现抗菌和持续的药物释放.
- 激光增材制造有助于创建具有增强药物载荷能力的植入物支架.
- 通过激光处理实现的分级多孔性结构允许按需释放药物.
结论:
- 激光处理是开发具有集成药物输送系统的先进骨科植入物的关键技术.
- 使用激光来定制微/纳米结构可以显著提高植入物性能并降低失效率.
- 对激光制造的进一步研究有可能为下一代骨科解决方案提供潜力.
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