环境污染物作为骨关节炎的新兴风险因素:机理学和流行病学证据
Hongmei Duan1, Feng Liang2, Lin Deng3
1Department of Rheumatology and Immunology, First Affiliated Hospital of China Medical University, Shenyang, China.
Ecotoxicology and environmental safety
|December 5, 2025
概括
环境污染物,如空气中的颗粒和重金属,通过损伤软骨和增加炎症,导致骨关节炎 (OA). 减少这些毒素的暴露对于预防关节退化和管理关节炎风险至关重要.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 类风湿病学 类风湿病学
背景情况:
- 骨关节炎 (OA) 是一种具有多因素原因的退行性关节疾病.
- 环境污染物越来越多地被认为是导致OA病变的因素.
- 了解化学物质暴露对OA的影响对于公共卫生至关重要.
研究的目的:
- 系统地审查和综合化学物质对OA暴露对机械和人口水平影响的证据.
- 阐明各种环境污染物如何促进骨关节炎的发展和进展.
- 确定知识缺口,并建议未来的污染物诱导的OA研究方向.
主要方法:
- 在体外,动物,计算和人类流行病学研究的系统综合.
- 对研究空气污染物,重金属,持久性有机污染物和内分泌干扰化学物质的研究进行分析.
- 评估机械路径,包括氧化应激,炎症和表观遗传修饰.
主要成果:
- 空气中的污染物 (PM2.5,PM10,NO2,O3) 和重金属 (,,) 与通过氧化应激和炎症增加OA发病率和软骨降解有关.
- 持久性有机污染物 (PCB,PFAS) 和内分泌干扰化学物质会破坏软骨平衡和骨软骨代谢.
- 流行病学数据显示,污染物暴露与OA流行,发病率和严重程度之间存在一致的关联,通常具有协同效应.
结论:
- 环境污染物是骨关节炎的重要,可修改的风险因素.
- 通过环境干预和公共卫生战略减轻污染物暴露对于预防关节退行至关重要.
- 未来的研究应该专注于纵向研究,生物监测,混合物效应和微塑料等新出现的污染物.
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