尿中DINCH度与类风湿性关节炎之间的关联:一个横截面研究
Jialin Zhang1, Xiangru Liu2, Shulv Quan3
1Department of Rheumatology and Immunology, The Eighth Affiliated Hospital, Southern Medical University(The First People's Hospital of Shunde, Foshan), Foshan, China.
Ecotoxicology and environmental safety
|December 5, 2025
概括
尿液中较高的DINCH (环素-1,2-二松尼尔) 含量与风湿性关节炎 (RA) 风险增加有关. 这种关联可能由维生素D介导,特别是在维生素D水平低的个体中.
科学领域:
- 环境健康 环境健康
- 类风湿病学 类风湿病学
- 毒理学 毒理学 毒理学
背景情况:
- 类风湿性关节炎 (RA) 的病因涉及环境因素.
- DINCH (环素-1,2-二乙烯乙) 是一种增塑剂,被认为比酸盐更安全,但其对健康的影响,特别是对RA,尚未完全理解.
研究的目的:
- 调查DINCH暴露与成人RA风险之间的关联.
- 探索维生素D的潜在调解,并确定易感性增加的子组.
主要方法:
- 利用了2013-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 采用多变量逻辑回归,趋势测试,调解和子组分析.
- 包括对缺失数据的敏感性分析.
主要成果:
- 尿中DINCH度的增加 (>1.0 ng/ml) 与较高的RA患病率有关 (OR = 1.44,P = 0.037).
- 通过维生素D观察到DINCH对RA的潜在间接作用 (介导效应为4.7%).
- 在血清中维生素D总水平较低的参与者中,这种关联更为强烈 (OR 1.79).
结论:
- 尿中DINCH度升高与类风湿性关节炎的更高患病率有关.
- 维生素D可能会调解DINCH暴露和RA之间的关系.
- 维生素D水平较低的人可能更容易受到DINCH暴露在RA风险上的不良影响.
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