优化环境监测,通过便脱落建模来早期检测动物传染病原体
Xin Du1, Zhiqiang Deng2, Yuqing Long1
1Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an, 710069, China.
Water research
|December 5, 2025
概括
表面水的监测可以检测动物感染的病原体,如流感A病毒 (IAV) 和Chlamydia psittaci. 这项研究制定了一个框架来评估其可行性,发现IAV可以与附近的感染进行检测,有助于流行病准备.
科学领域:
- 环境微生物学与公共卫生
- 动物传染病监测监测动物传染病.
- 传染病流行病学传染病流行病学
背景情况:
- 动物传染病原体对全球健康构成重大挑战.
- 使用基于地表水的监测 (SWBS) 的具有成本效益的早期预警系统尚未得到充分探索,尤其是在资源较少的环境中.
- 了解病原体分泌对于制定有效的监测策略至关重要.
研究的目的:
- 分析人类和鸟类中克拉米迪亚虫和流感A病毒 (IAV) 的便分泌模式.
- 开发一个理论框架来评估SWBS对这些动物传染病原体的可行性.
- 为在资源有限的环境中优化环境监测设计提供数据驱动的方法.
主要方法:
- 在患者和鸟类样本中分析C. psittaci和IAV的便流失模式.
- 开发一个新的理论框架来评估SWBS的可行性.
- 蒙特卡洛模拟用于预测表面水和下水道的病原体检测能力.
- 在三个下水道区进行前性环境监测验证.
主要成果:
- 在Cloacal swab中检测到C. psittaci (8-16%) 和IAV (16-84%) 的高阳性率,因鸟类物种而异.
- 在人体便中观察到IAV (44.7%) 和C. psittaci (37.6%) 的显著脱落率.
- 预计IAV在附近感染的鸟类或人类病例的地表水中可量化;在社区污水中发现C. psittaci被认为不太可能.
结论:
- SWBS是一种潜在的可行策略,用于在地表水中检测IAV,特别是在鸟类或人类感染率高的地区.
- 与IAV相比,C. psittaci在社区污水中通过SWBS检测的可能性较小.
- 该研究建立了一个强大的,数据驱动的方法,以优化环境监测,增强疫情防控和预警系统.
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