纳米颗粒中封装的甘酸/阿斯特拉加卢斯多糖:增强稳定性,生物活性和持续释放
1School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China.
Food chemistry
|December 5, 2025
概括
这项研究开发了稳定的ain-Astragalus多糖纳米颗粒封装糖酸 (GA). 这些纳米粒子显著改善了GA.
科学领域:
- 药理学和药物输送 药理学和药物输送
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 糖酸 (GA) 具有显著的抗病毒,抗炎和肝脏保护性质.
- 由于GA在各种条件下 (pH,温度) 的稳定性不佳,GA的治疗潜力受到限制.
- 基于纳米粒子的输送系统为提高生物活性化合物的稳定性和生物可用性提供了一个有希望的策略.
研究的目的:
- 开发和表征新型的Astragalus多糖纳米颗粒 (zein-APS-GA NPs) 以提高糖酸 (GA) 的稳定性和传递性.
- 评估开发的ain-APS-GANP的体外生物可访问性,抗氧化活性和稳定性.
- 评估zien-APS-GANP对AML-12细胞中酒精诱导的肝损伤的细胞保护功效.
主要方法:
- 齐恩-阿斯特拉加勒斯多糖化物纳米颗粒 (zein-APS-GA NPs) 是通过封装糖酸 (GA) 来合成的.
- 纳米颗粒的特征包括尺寸,多分散度指数和封装效率.
- 实验室模拟消化,抗氧化剂测试 (激素清除),稳定性测试 (离子强度,pH,温度,储存) 和细胞活力测试 (酒精受损的AML-12细胞) 进行.
主要成果:
- 优化的 zein-APS-GA NP 的颗粒大小为 101.10 nm,多分散度指数为 0.092,封装率高达 91.70%.
- 在模拟消化后,纳米颗粒显示显著增强生物可访问性 (72.84%) 与自由GA (30.70%) 相比.
- Zein-APS-GA NPs表现出强大的激素清除活性 (66.23%-73.34%),并在室温下48小时后保持超过40%的活性,在各种离子强度,pH值和温度下保持稳定.
- 与自由GA (63.29%) 相比,纳米颗粒显著提高了受酒精损伤的AML-12细胞的活力 (95.50%).
结论:
- 齐恩-阿斯特拉加勒斯多糖化物纳米颗粒有效地增强了糖酸的稳定性,生物可访问性,抗氧化能力和细胞保护作用.
- 已开发的 zein-APS-GA NP 是一个有前途的药物输送系统,可以提高糖酸的治疗效果,特别是用于保护肝脏.
- 这种配方克服了自由糖酸的稳定性限制,为潜在的治疗应用铺平了道路.
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