HPMC-GG微囊可同时提供曼诺斯和黄素:功能性食品中增强肠道向性
Xianglong Wang1, Xiaofu Liang1, Zijian Qiu1
1College of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China.
Food chemistry
|December 5, 2025
概括
新型基甲基纤维素-瓜尔口香糖微囊 (HPMC@GG MPs) 能够有效地携带难溶的生物活性化合物. 这种食品级系统提高了功能性食品的生物可用性和稳定性.
科学领域:
- 食品科学与技术 食品科学与技术
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 基于多糖的输送系统对于提高功能性食品中生物活性化合物的生物可用性至关重要.
- 曼诺和黄素具有不同的溶解度,可以作为模型生物活性物质.
- 开发用于同时提供多种生物活性物质的系统具有挑战性.
研究的目的:
- 创建基基甲基纤维素-guar微囊 (HPMC@GG MPs) 用于同步肠道向释放曼诺和黄素.
- 为了研究这些微囊的封装,稳定性和释放动力学.
- 建立一个可扩展的,食品级平台,以共同提供具有对比溶解度的生物活性物质.
主要方法:
- 用于制造HPMC@GG MPs的喷雾干燥技术.
- 使用FTIR,DSC,XRD和拉曼光谱进行表征,以确认无形封装和矩阵形成.
- 在不同的pH值下进行体外释放研究,以评估释放动力学 (零序,超级案例II运输).
- 分子动力学模拟以阐明相互作用机制.
主要成果:
- HPMC-GG矩阵形成了一个强大的3D结网络,使无形封装成为可能.
- 优化的CM-HPMC@GG-1:2MP显示持续释放:曼诺斯 (83.4%在12h,零级),黄素 (86.6%肠道释放,pH依赖的超级案例II运输).
- 高封装效率 (曼诺:84.2%,黄素:81.9%) 和黄素增强的热稳定性 (55%对34%的保留率).
结论:
- 开发的HPMC@GG MPs提供了一个可扩展的食品级平台,用于共同提供具有不同溶解度的生物活性物质.
- 这种系统显著提高了封装化合物的生物利用性和稳定性.
- 这些发现推动了具有增强治疗潜力的功能性食品的设计.
相关概念视频
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
184
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
184
Bioavailability Enhancement: Drug Permeability Enhancement
176
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
176
Drug Delivery: Enteral Route
1.5K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.5K
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
1.0K
The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
1.0K


