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Ting Zou¹, Xuyang Wang¹, Xiaofei Hu²

¹The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, PR China; MOE Key Laboratory for Neuroinformation, Brain-Computer Interface & Brain-Inspired Intelligence Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, PR China.

NeuroImage. Clinical

|December 5, 2025

概括

研究人员根据大脑解剖学和基因表达确定了两种不同的帕金森病 (PD) 亚型. 这些亚型显示出不同的大脑变化模式和遗传联系,改善了我们对PD异质性的理解.

科学领域:

神经成像是一种神经成像.
遗传学遗传学是一个
神经退行性疾病神经退行性疾病

背景情况:

帕金森病 (PD) 是一种复杂的神经退行性疾病,已知特定区域的大脑解剖变化.
在PD亚型中这些解剖异常的遗传基础在很大程度上是未知的.

研究的目的:

为了研究帕金森病中不同的神经解剖学亚型.
为了发现与每个PD亚型的形态学异常相关的全脑基因表达模式.
为了弥合神经成像和转录学之间的差距,了解PD异质性.

主要方法:

对127名PD患者和101名健康对照 (HC) 的MRI数据应用的形态逆分歧 (MIND) 算法.
通过差异分析 (HYDRA) 的异质性用于根据MIND强度识别PD亚型.
部分最小平方 (PLS) 回归将MIND网络变化与基因表达联系起来,然后进行功能丰富和细胞类型分析.

主要成果:

确定了两种不同的PD亚型:亚型1显示前额/皮层的MIND下降;亚型2显示尾部/中后皮层的MIND增加.
两种PD亚型都表现出认知障碍;亚型2的UPDRS-III和H&Y分数低于亚型1.
基因分析显示了5个共享的负基因. 1亚型基因与突触功能,神经发育和退行有关; 2亚型基因还涉及代谢途径和星球细胞.

结论:

确定了帕金森病的两个不同的神经解剖学亚型,突出了PD的异质性.
在每个亚型中证明了神经解剖学变化和基因表达模式之间的特定关联.
这些发现提供了转录学和神经成像学之间的桥梁,促进了对PD复杂机制的理解.

关键词:

在 AHBA 数据集中,通过差别分析的异质性.形态学上的相似性帕金森病是帕金森氏症的一种疾病.部分最小平方回归.

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