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Updated: Jan 9, 2026

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胃癌发生中的IL-17轴:从炎症到瘤转化
Zhaojie Lyu1, Mancang Gu2, Zhengmao Lu3
1Institute of Precision Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, China.
Cytokine & growth factor reviews
|December 5, 2025
概括
干白素-17 (IL-17) 在胃癌 (GC) 发展中起着双重作用,促进炎症和瘤生长,同时也可能增强抗瘤免疫力. 针对IL-17通路,特别是IL-17RC,为GC提供了治疗潜力.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 胃癌 (GC) 是一个主要的全球健康问题,受到Helicobacter pylori (Hp) 感染和慢性炎症的重大影响.
- 介质蛋白-17 (IL-17) 与免疫失调和瘤发生有关,但其在GC中的确切作用是复杂的,需要进一步阐明.
研究的目的:
- 综合审查IL-17在胃瘤发生过程中的分子机制,包括它在HP驱动炎症中的作用.
- 评估IL-17对GC发作,进展,转移和治疗耐药性的影响.
- 探索IL-17轴在GC中的治疗影响和生物标志物潜力.
主要方法:
- 系统审查现有关于IL-17在GC中的信号传递的文献.
- 对分子通路 (NF-κB,STAT3),矩阵金属蛋白酶 (MMP) 和血管生成因子的分析.
- 对IL-17通路抑制的流行病学数据和临床前/临床研究的评估.
主要成果:
- IL-17增强HP诱导的炎症,促进瘤生长,并通过NF-κB和STAT3激活促进血管生成.
- IL-17有助于瘤微环境重塑,免疫抑制和治疗耐药性.
- IL-17表现出上下文依赖的双重作用,可能增强抗瘤免疫力和细胞毒性T细胞反应.
结论:
- IL-17在胃癌中具有复杂的双重作用,影响瘤促进和抗瘤免疫力.
- 针对IL-17通路,用IL-17RC作为潜在的生物标志物,为个性化GC治疗提供了一个有前途的战略.
- 需要进一步的研究,以平衡免疫抑制风险与IL-17通路抑制在GC中的治疗益处.
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